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Macrophage migration inhibitory factor (MIF) is undoubtedly an inflammatory cytokine that serves numerous roles in inflammation and immunity; on the other hand, It is usually linked to carcinogenesis. this can be a evaluate in the clinical and experimental details published on MIF and its job in different types of cancers for instance glioblastomas, lung most cancers, breast most cancers, gastric cancer, melanoma, bladder most cancers, and head and neck cancers.
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Besides MIFs immunogenic part, it's also been claimed to Perform a significant function through neural embryonic improvement. Shen et al. (2013) shown the MIF pathway is needed for that survival of statoacoustic ganglia and sensory hair cells in the zebrafish design. employing knockdown with antisense oligonucleotide morpholinos (MOs) and/or by using a biochemical MIF inhibitor, four-IPP, there was a major reduction in the dimensions in the SAG, the quantity of sensory HC, and the size on the brain in zebrafish.